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Diet Pills

Qsymia

Qysmia is an FDA-approved medication for long-term weight loss. It is a combination of two well-known drugs, phentermine, and topiramate. This synergistic combination is what makes this medication unique. It works by decreasing appetite and food consumption. 

Qsymia is the only once daily FDA approved diet pill for long term weight loss. It is unique because it is the first weight loss drug to be approved by FDA in over 15 years due its unique synergistic effect.

It is a unique combination of two well-known drugs, phentermine and topiramate, but new formulation.
The main difference is summation of effect without summation of side effects. For that reason, at Allergy and weight Loss center and Concord weight loss center we use Qsymia for short-term and long-term weight loss

Qsymia or Qnexa?
Qsymia had been known as Qnexa until its approval. The FDA asked the company to change the name to avoid confusion with another drug on the market, according to the company.

Qsymia is a combination of Phentermine and Topiramate.

Phentermine is an appetite suppressant. It triggers the release of norepinephrine in the brain, which increases blood concentrations of leptin, an appetite-regulating hormone.

Topiramate, commonly known as Topamax, is prescribed as an anticonvulsant and migraine medication. It can aid in weight loss by increasing the feeling of being full, making foods taste less appealing and increasing calorie expenditure.

Read more:  http://www.foxnews.com/health/2012/07/25/all-need-to-know-about-qsymia/#ixzz2N1Ta1wLX

Qsymia is indicated for weight loss if

  1. If your BMI is over 30 or
  2. If your BMI is more than 27 with medical problems such as hypertension, diabetes, high cholesterol, sleep apnea, heart disease, stroke, PCOS etc.
  • Must NOT be pregnant, trying to get pregnant, or unable/unwilling to comply with contraceptive guidance
  • No known hypersensitivity or idiosyncrasy to the sympathomimetic amines
  • No glaucoma
  • No hyperthyroidism
  • Not using monoamine oxidase inhibitors (MAOIs) or have not used within 14 days
  • No known hypersensitivity or idiosyncrasy to the sympathomimetic amines
  • Qsymia is Class IV controlled drug.Qualified medical doctor faxes the prescription to central pharmacies like Walgreen, Express Scripts, or CVS
  • Medication is shipped to your home address directly
    The first order includes two weeks starter dose, and one additional month’s supply
  • Qsymia cannot be filled by local pharmacy or by any online pharmacy.

Qsymia is available as phentermine hydrochloride (as the free base)/topiramate extended-release gelatin capsules in the following strengths and colors:

  • 3.75 mg/23 mg [Purple cap imprinted with VIVUS, Purple body imprinted with 3.75/23]
  • 7.5 mg/46 mg [Purple cap imprinted with VIVUS, Yellow body imprinted with 7.5/46]
  • 11.25 mg/69 mg [Yellow cap imprinted with VIVUS, Yellow body imprinted with 11.25/69]
  • 15 mg/92 mg [Yellow cap imprinted with VIVUS, White body imprinted with 15/92]
  • Qsymia side effects are much less than the individual components of phentermine and topiramate because Dose of phentermine is much less than usually used in weight loss clinics
  • Top dose in Qsymia is 15 mg of phentermine as opposed to 37.5 mg Dose of topiramate is much less than used for migraine prevention ro seizure disorder.
  • Top dose in Qsymia is 92mg as opposed to 300-400mg Combination of the drugs cancel out the upper/downer side effects

Contrave

Contrave is an FDA-approved medication for long-term weight loss. 

Contrave combines two drugs that are already on the market: 

Bupropion (Wellbutrin) is an antidepressant that works by inhibiting the neuronal reuptake of dopamine and norepinephrine.  

Naltrexone is an anti-addiction drug that works as an opioid antagonist. 

It decreases appetite and cravings. It may be a good option for patients suffering from depression.  

Contrave, the new prescription weight loss drug to be approved by the FDA in 2014.

Contrave joins Qsymia (phentermine and topiramate) and Belviq (lorcaserin). Both were approved in 2012.

Contrave combines two drugs already on the market:

Bupropion (Wellbutrin), an antidepressant, (inhibitor of the neuronal reuptake of dopamine and norepinephrine) and
Naltrexone, an anti-addiction drug (opioid antagonist).

Bupropion, the same active ingredient as some other antidepressant medications ( WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL and APLENZIN)

Naltrexone is marketed in generic form as naltrexone hydrochloride, and marketed under the trade names Revia and Depade. In some countries including the United States, a once-monthly extended-release injectable formulation is marketed under the trade name Vivitrol. Also in the United States, Methylnaltrexone Bromide, a closely related drug, is marketed as Relistor, for the treatment of opioid induced constipation.

Naltrexone should not be confused with naloxone nor nalorphine, which are used in emergency cases of opioid overdose.

Naltrexone and bupropion have effects on two separate areas of the brain involved in the regulation of food intake:

  • Hunger center: Hypothalamus (appetite regulatory center) and
  • Craving center: Mesolimbic dopamine circuit (reward system).

http://www.contrave.com/Images/howto-dosing-table.png

More information about Contrave:

Visit Contrave Home Page

GLP-1 agonist Injectables

Saxenda is an FDA-approved medication for long-term weight loss. Other common brand names include: Wegovy (semaglutide) and Ozempic (semaglutide).

It is a take-home injectable pen injected once weekly under the skin (subcutaneously) in your stomach area, upper leg, or upper arm. It mimics the naturally occurring hormone GLP-1 in your intestine secreted when you eat food. It reduces food intake, increases the feeling of fullness, and improves blood sugar metabolism. 

Saxenda is very different from all other weight loss drugs.

  • GLP-1 activates specific areas in the brain that regulate appetite and food intake affecting: Fullness, Satiety (satisfaction with a meal), and Hunger
  • It is a once-a-day injection instead of a pill. For another, it works by mimicking the naturally occurring hormone GLP-1 in your intestine secretes when you eat food.
  • The hormone-mimicking drug in Saxenda, Liraglutide, was originally marketed as Victoza, prescribed to treat diabetes.
  • Like other medications used for diabetes, it introduces a hormone that compensates for a deficiency.
  • Saxenda is essentially a double dose of Victoza, and after much testing, the FDA approved it for weight loss in December 2014.
  • It was discovered that a “side effect” of Victoza was weight loss.
  • It can be used effectively long term, for chronic management of obesity.
  • It is not like the appetite suppressant weight loss drugs that only work for a while.

Phentermine

It is an appetite suppressant commonly used for weight loss. 

Phentermine works by activating your sympathetic (“fight or flight”) nervous system to release norepinephrine in the brain resulting in decreased appetite and food intake. 

Topiramate

You may have heard of this medication because, at higher doses, used for seizures or migraines and at much lower doses used for weight loss. 

Topiramate helps decrease appetite and cravings. It may be beneficial for patients with binge eating disorders.

Metformin

Insulin resistance happens when the cells in your body cannot use insulin effectively, thus affecting the regulation of blood sugar. It is a significant contributor to weight gain.  

Metformin works by improving the regulation of blood sugar and reducing insulin resistance. It also decreases appetite and increases fullness.  

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